Phenotyping of genetically engineered mice

Updated: 2014-03-04 in: Animal experiments in research

Phenotyping of genetically engineered mice (2.0 ECTS)

The course teaches how genetically engineered mice can be phenotyped in a strategic way. 

Aim 

The course aims to teach the basic biology of the laboratory mouse in its context of genetically modified animal models. It will provide an overview of available endpoints, and of the various types of results obtained from different analyses and highlight their complementary value as well as limitations. 

Apply for the course 

Next course round starts 25 november. The course has no available spots. A start date for the next course round has not yet been set. 

Key topics

  • Systematic phenotyping analysis
  • Transgenesis methodology
  • Breeding of genetically modified mice
  • Imaging techniques
  • Perfusion fixation
  • Necropsy techniques
  • Post mortem tissue preparation

Why is the course important for KI's researchers?

Phenotyping is a broad term that encompasses the integrated recording of a set of biological parameters both on clinical and tissue level, to characterize a condition in an organism. Phenotyping is typically useful to characterize genetically engineered organisms. Successful integrated phenotyping of genetically engineered mice helps researchers identify areas of interest associated with genetic condition, adding to our understanding of gene function and regulation. 

Key note speakers

Cory Brayton, Associate Professor of Molecular and Comparative Pathobiology from Johns Hopkins University and Björn Rozell, Professor at the Department of Veterinary Disease Biology at the University of Copenhagen.  

Course start date

Next course round will be autumn 2015. 

Location

The course location is Karolinska Institutet, Campus Solna.