Phenotyping of genetically engineered mice
The course aims to teach the basic biology of the laboratory mouse in its context of genetically modified animal models. It will provide an overview of available endpoints, and of the various types of results obtained from different analyses and highlight their complementary value as well as limitations.
The course is on the doctoral level (2.0 ECTS) but open for post docs and researchers.
Course start dateDecember 4-8, 2017
- Systematic phenotype analysis
- Transgenesis methodology and breeding
- Selection of controls
- Mouse biology, strain differences and characterization
- Necropsy techniques, perfusion fixation
- Post mortem tissue preparation for histology
- Imaging techniqu
Why is the course important for KI's researchers?
Phenotyping is a broad term that encompasses the integrated recording of a set of biological parameters both on clinical and tissue level, to characterize a condition in an organism. Phenotyping is typically useful to characterize genetically engineered organisms. Successful integrated phenotyping of genetically engineered mice helps researchers identify areas of interest associated with genetic condition, adding to our understanding of gene function and regulation.
The course is free for PhD students registered at KI. For all other participants and PhD students from other universities the course fee is 9200 SEK including INDI.
The course location is Karolinska Institutet, Campus Solna.
Raoul Kuiper, PhD, DVM Dipl. ECVP Pathology, Karolinska Institutet